Neonatal Candida Albicans Meningitis: Report of One Case

新生兒白色念珠菌腦膜炎：一病例報告

夏文傑(Wen-Jye Shian) ； 遲景上(Ching-Shiang Chi) ； 王德明(Teh-Ming Wang)

《Acta Paediatrica Sinica》 34卷1期 (1993/02) Pp. 22-26

摘要

一個21天大的足月產男嬰，曾經在出生後因胎便吸入，而接受抗生素及呼吸器治療。這次入院主訴是發燒，頸僵硬及活力差，在細菌性敗血症的臆斷之下，投予靜脈抗生素；但是在住院第七天的第三次及第十三天的第四次腦脊髓液培養，結果均是白色念珠菌，自此投予靜脈amphoter-icin B 38天治療，其後三次腦脊髓液培養均為陰性，而且病人活力改善並無發燒，腦部超音波檢查正常，情況穩定下出院。我們報告此病例並回顧文獻資料，希望能夠在重症加護日益精進的今日，能謹記住這日益增多的念珠菌腦膜炎疾病。

並列摘要

Candida meningitis is a growing problem today. We report a 21-day-old male baby who was a victim of Candida albicans meningitis with the initial presentations of fever, mild stiff neck, poor feeding and activity. He had been treated with intravenous antibiotics and ventilator therapy prior to admission Initially, he was treated as a case of bacterial sepsis after admission with intravenous antibiotics. Due to positive cultures of cerebrospinal fluid for Candida albicans twice, intravenous amphotericin B was started from the 13th hospital day and was continued for 38 days. The successive three sets of CSF fungus culture yielded negative results and the patient was doing well without fever. Meanwhile, the brain sonogram revealed normal findings and he was discharged in a stable condition. We report this case and review some literature in an attempt to know more about this unusual disease, which is becoming more frequent as progress in intensive care grows.

並列關鍵字

Candida albicans meningitis ； amphotericin B ； neonatal meningitis