The Therapeutic Outcome of Medulloblastoma in 49 Children

49 例孩童神經管胚細胞瘤之治療效果

江東和(Tang-Her Jaing) ； 洪悠紀(Iou-Jih Hung) ； 楊兆平(Chao-Ping Yang) ； 王煇雄(Huei-Shyong Wang) ； 洪伯誠(Po-Cheng Hung)

《Acta Paediatrica Sinica》 36卷4期 (1995/08) Pp. 279-285

https://doi.org/10.7097/APS.199508.0279

摘要

在63位神經管胚細胞瘤的病例中，有49位經組織确認且接受治療。本篇采回溯性研究來分析這49位病例的臨床表微及治療結果。其中有41位病例在腫瘤切除後，并對後腦窩和其它侵犯組織進行顱脊放射線療法；有20位接受化學治療，17位為手術後之輔助療法，3位為放射線治療前的化學治療。這49位病例之手術後初期死亡率為4.08%，五年存活率和無再發存活率分別為78%和19%），和安全放射線治療的病例（五年存活率和無再發存活率分別為70%和57%），其預後較佳。

關鍵字

孩童之神經管胚細胞瘤

並列摘要

The medical records of 63 patients with histologically-confirmed medulloblastoma were reviewed. From these, the clinical features and treatment outcome of 49 patients were available for analysis. Following tumor resections, 44 patients were given craniospinal radiation therapy with local boosts to the posterior fossa and other inacroscopically involved areas. Twenty patients received chemotherapy: 17 as postoperative adjuvant or salvage therapies, and 3 as preradiation chemotherapy. The postoperative early death occurred in two patients. The projected 5-year survival and recurrence-free survival rate of the overall group and the 41 patients who had completed radiotherapy were 61%, 70% and 50%, 57%, respectively. Two significant favorable factors were identified: complete tumor resection and combination radiotherapy. A better five-year survival rate was found in patients who had complete tumor resection (78% vs 19%); with combination radiotherapy the rate was 70% vs 0%.

並列關鍵字

medulloblastoma in children