The major pathology of ischemic Heart Disease (IHD) is an imbalance between oxygen supply and demand resulted usually from the lack of oxygen due to inadequate myocardial blood perfusion. Management of the IHD includes either reduction in myocardial oxygen demand or elevation in coronary blood flow. On basis of generalized concept for diagnosis and treatment in Chinese Medicine. It is the most important principle for treatment of IHD by coordinating the Qi and Blood of the Five Viscera. It serves to satisfy and regulating the energy and blood perfusion of all vital organs. Meanwhile, it's thought to be beneficial to the heart by stabilizing the blood flow of myocardium and reducing load of the heart. The assay from the distinguished Chinese physician experience and our observation in clinic. The thinking process of coordinating the Qi and Blood of the Five Viscera is through by regulating the systemic Qi and Blood that can improve myocardial blood perfusion and ischemia as well as enhance the life quality of coronary heart disease.