Cause, location, pathological character and dynamic of disease are the four major factors of the bowels and viscera pathomechanism. Anyway the disease how highly varied conditions; it will know the rules of disease pathogenesis and development only according the four major factors of the bowels and viscera pathomechanism following analysis. The analysis of cause and pathomechanism of the disease is an important training cause for elevated clinic ability of the Chinese physician residents. The present paper is made partial correct according the four major factors of the bowels and viscera pathomechanism, and offers an established step of the bowels and viscera pathomechanism with four major factors. On the other hand, it offers an experienced treatment principles of prescription and drug use on bases of simple and combined pathomechanism.