Sixty two disease patterns from Nei jing classic were recorded in Xuan ming lun wroted by Liu-Wan-Su in Chin-Yuan Dynasty. The present was researched pathomechanical theory of the sixteen disease patterns. The causes of external contraction of the six excesses were wind and cold evil, and the internal damage was appreciated cold, heat, vacuity and repletion of bowels and viscera. Among of them yang vacuity yin exuberance, bowel heat transfer to bowel, and viscera hear or cold transfer to viscera were the character of pathomechanical theory. The medicinal used in clinic of sixteen disease patterns were divided five kinds of wind and cold dispelling medicinal, boosting qi and supplementing blood medicinal, warm the center and dispel cold medicinal, warm and supplement the life gat medicinal and cold cooling and drain fire medicinal. Physicians over the ages though Liu-Wan-Su was a created scholar of cold and cooling school. But Liu's prescriptions contained cold and cooling as well as drain fire drugs for treating Nei jing sixty two disease patterns were not play an important role. The causes of Nei jing sixteen disease patterns commonly were internal factors of yang vacuity yin exuberance or viscera cold transfer to viscera. So most therapeutic herbs were included boost qi and supplement blood, warm the center and dispel cold, warm and supplement the life gat medicinal. If the treatment combined with external contraction of wind and cold evil, dispelling wind and cold medicinal would be administered.