The subject research of stomach domain repletion in Yang brightness disease by Shang Han-Lun worted by Zhang Zhong-Jing was mainly gastro-intestinal system disease and liver disease. The acute abdomen, Straitened Spleen, functional constipation. chronic enteritis, and stomach vacuity cold pattern were included in the gastro-intestinal ststem. Among of the gastro-intestinal ststem disease, acute abdomen disease was a study of key point. The intestinal obstruction caused by dry feces was an important factor of acute abdomen. The liver diseases included hepatic jaunce disease and liver decompensation were the key point of researched subject. The following formulas as Ephedra, Forsythia, and Rice Bean Decoction, Virgate Wormwood Decoction, and Gardenia and Phellodendron Decoction were used to treat jaundice pattern of Yang brightness disease. Polyporus Decoction was treated ascite caused by liver decompensation. The clinic course of acute abdomen was divided three stage, White Tiger Decoction and White Tiger Decoction Plus Ginsengand were the formulas with anti-pathogen and resolved fever action treated initial stage of infection. The second stage of pre-delirium and delirium, Stomach-Regulating Qi-Coordinating Decoction was a pre-delirium treatment of formula, whereas Major and Minor Qi-Coordinating Decoction were an indicational formulas of treatment of delirium. The late stage of acute abdomen course was a metabolic intoxication of brain even caused of coma and poor of prognosis.