- 期刊
Malignant Hyperthermia with Excellent Response to Small Dose of Dantrolene
對小劑量Dantrolene有良好反應之惡性高熱的病例報告
摘要
惡性高熱是一種與全身麻醉有關的麻醉急症，早期診斷與迅速處理是惡性高熱的治療重點。Dantrolene是治療的首選藥物，所有施行全身麻醉的醫療機構都應該準備此藥物以應付可能的狀況。但是，其相對的高價格與只有三年的保存期限使得建議的大量藥品准備似乎值得再做進一步地討論，尤其對甚少施行全身麻醉的小醫院來說更是如此。我們提出兩個對小劑量dantrofene即有良好反應的病例報告，並討論可行的處理方法，同時探討更少的dantrolene準備量對小型醫療機構來說是否不失為一可行的替代方案。
並列摘要
Malignant hyperthermia (MH) is an operative emergency associated with general anesthesia. Early diagnosis and prompt treatment are the keynotes in management of MH. Dantrolene is the only specific drug and all of the institutions where general anesthesia is a daily routine should have a stockpile of this drug for the rare occurrence of MH. Nonetheless, the enormous expenditure on stockpile and 3-year validity make a large reserve of the drug to forestall 11H, a disorder of rare occurrence, seems disputable, especially in small hospitals where general anesthesia is seldom practiced. We herein report two cases of MH with excellent response to small doses of dantrolene and then discuss the way of practicable management and debate on the question of whether fewer stock of dantrolene is an alternative way for hospitals of smaller scale.
延伸閱讀
- 沈雅敏、蕭詩立（2020）。低劑量Dantrolene治療惡性高熱之案例報告。醫學與健康期刊，9(3)，95-100。https://www.airitilibrary.com/Article/Detail?DocID=23046856-202011-202011300018-202011300018-95-100
- 鄭春秋（2006）。化學治療引起之嗜中性球減少症合併高體溫。腫瘤護理雜誌，6(1)，9-17。https://doi.org/10.6880/TJON.200606_6(1).02
- 戴志勳（2007）。超廣效乙內醯胺酶之克雷白氏肺炎桿菌菌血症：死亡危險因子及臨床治療結果分析，著重於藥物治療結果〔碩士論文，國立臺灣大學〕。華藝線上圖書館。https://doi.org/10.6342/NTU.2007.01327
- Lee, I. C., Chen, Y. J., & Fang, P. C. (2007). 中心蕊疾病合併惡性高溫之家族史：一病例報告. Acta Paediatrica Taiwanica, 48(4), 217-219. https://doi.org/10.7097/APT.200708.0217
- Dai, H. Y., Chen, C. L., Chung, C. L., & Wang, F. C. (2009). 使用低劑量，短期Amiodarone所導致之器質化肺炎－個案報告. 胸腔醫學, 24(6), 339-345. https://doi.org/10.29806/TM.200912.0006