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口服製劑中Loperamide Hydrochloride定量法之研討

Studies on the Methods of Quantitation of Loperamide Hydrochloride in Oral Preparations

摘要


常用於Loperamide Hydrochloride錠劑、膠囊劑及糖漿劑之含量測定法有(一)非水滴定法,(二)紫外光吸光度測定法及(三)可視光吸光度測定法。經研討,其中仍以經加溴瑞香酚藍、溴甲酚綠或脫羅漂林OO等呈色劑使其磺醯基(sulfonyl group)與Loperamide Hydrochloride中鹽基性基作定量的結合而呈色之可視光吸光度測定法最為精確、實用。

關鍵字

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並列摘要


Three methods, i.e. the ultra violet spectrophotometry, non-aqueous titration and colorimetric method used in. the determination of the content of Loperamide Hydrochloride in oral preparations were described and discussed in the aspect of their practicabilities. It was found that the colorimetric method was the most practical and precise one.

並列關鍵字

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