- 期刊
Percutaneous Absorption of Indomethacin from Ointment Following Repeated Administration in Rabbits
重覆投與吲跺美洒辛軟膏於兔子的經皮吸收研究
摘要
本研究以家兔為實驗動物，比較吲跺美洒辛軟膏經單次或重覆貼敷於同樣部位後的經皮吸收情形。將吲跺美洒辛吸收軟膏貼覆於腹部，每次之貼覆時間相同經重覆投與後，吲跺美洒之吸收量顯著地比單次投與後為高。 局部單次或重覆軟敷吲跺美洒辛吸收軟膏後，將吲跺美洒辛經皮吸收所得之經時血漿濃度與時間的函數關係式來表示。可發現僅重覆貼敷於背部後之經時吲跺美洒辛之血漿濃度變化大略符合將單次貼敷後所求得之動力學參數值代入血漿濃度與時間的函數關係式中計算而得的經時血漿濃度變化。
關鍵字
無資料並列摘要
The percutaneous absorption of indomethacin following short- and long- term administration of indomethacin absorption ointment to the same skin surface in the rabbits were compared in this study. The level of absorption of indomethacin as reflected by plasma concentration was significantly increased by the repeated applications of the indomethacin absorption ointment on the abdominal site. A pharmacokinetic model was derived to analyze the percutaneous absorption after being repeatedly administrated to the rabbits. The model can fairly describe the plasma level curves of indomethacin from the 1st day to the 8th day during which the drug was applied on the dorsal site for 10-h every day.
延伸閱讀
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