Tumor Induction Through Varying Lengths of Carcinogen Exposure

倉鼠口腔頰囊袋病變與誘癌劑塗擦時間長短之關係

林立民(Li-min Lin) ； Kent A. Heideman ； Patrick D. Toto

《The Kaohsiung Journal of Medical Sciences》 2卷6期 (1986/06) Pp. 394-400

https://doi.org/10.6452/KJMS.198606.0394

摘要

倉鼠口腔頰囊袋塗抺誘癌劑0.5%之二苯甲葸(9.10-dimethyl-1.2-benzanthracene, DMBA)，每週二次連續到十二週之久。在第七週觀察時，臨及組織切片上均顥有乳突瘤的形成，而七週到十二週之間，倉鼠口腔頰囊袋的變化漸由乳突瘤轉變為嚴重增生之癌前變化，最後轉變為惡性扁平鱗狀細胞上皮癌。誘癌劑的塗擦時間愈長，病變形成的癌愈為顯著。

並列摘要

Squamous cell carcinomas and papillomas were induced in the buccalmucosa of the left cheek pouch of Golden Syrian Hamsters using 9,10-dimethy1-1, 2-benzanthracene (DMBA). Applications of a 0.5 percent solution of DMBA in mineral oil were made biweekly. Treatment and observation was for a period of 12 weeks after which the cheek pouch was inverted, excised and histological slides were prepared from the tissue. Tumors and papillomas were observed in all groups painted seven through twelve weeks. Those painted for seven weeks demonstrated papillomas. The changes from seven weeks onward progressed from papillomas to carcinoma. The longer the groups were painted, the more severe were the lesions.

並列關鍵字

carcinogen ； induction ； DMBA