小白鼠感染廣東住血線蟲之顱內移行研究

Study on Intracranial Migration of Angiostrongylus Cantonensis in Mice

黃高彬(Kao-Pin Hwang) ； 陳瑩霖(Eng-Rin Chen)

《The Kaohsiung Journal of Medical Sciences》 4卷1期 (1988/01) Pp. 10-14

https://doi.org/10.6452/KJMS.198801.0010

摘要

為了解小白鼠感染廣東住血線蟲後，幼蟲在其顱內存活的情形，本研究分別以30，40和50隻廣東住血線蟲第三期幼蟲感染ICR(Institute for Cancer Research)雌性小白鼠，由感染後540天幼蟲回收數來決定感染的適當蟲數和小白鼠體重及年齡的關係。結果發現感染30，40或50隻廣東住血線蟲第三期幼蟲的小白鼠，其顱內幼蟲回收數依感染後日數漸增，至第20天時達到各組的最高峯，以後漸減，在第35天時回收率降至18%以下。感染50隻幼蟲者，回收蟲數高於30隻和40隻幼蟲。小白鼠體重13至19公克感染50至30公克的鼠群。死亡的小白鼠發現其顱內蟲數多於感染後同時期血線蟲的動物模式。

並列摘要

ICR (Institute for Cancer Research) female mice were infected with 30, 40 or 50 third stage larvae of Angiostrongylus cantonensis and sacrificed 5-40 days after infection. Cervical dislocation was performed and brains of mice were examined for A. cantonensis larvae under the disecting microscope. The highest number of worms recovered from brains of mice was observed 20 days following infection and the recovery rate of worms declined to 18% 35 days after infection. The worm recovery rate in mice infected with 50 larvae was higher than that infected with 30 and 40 larvae. The worm number, 5 and 10 days post-infection, recovered from brains of mice weighed 13 to 19g was higher than that of mice weighed 20 to 30g. Compared with the dead mice during the experiment, worm number in brains of surviving mice was significantly lower. It is concluded that ICR mice could be used as animal models for chemotherapeutic experiments in Angiostrongylus cantonensis infections.

並列關鍵字

Angiostrongylus cantonensis ； intracranial migration