Circulating Immune Complexes in Patients with Systemic Lupus Erythematosus

系統性紅斑狼瘡病人之循環免疫複合體

顏正賢(Jeng-Hsien Yen) ； 劉宏文(Hong-Wen Liu) ； 林勝豐(Sheng-Fung Lin) ； 陳忠仁(Jong-Rern Chen) ； 陳田柏(Tyen-Po Chen)

《The Kaohsiung Journal of Medical Sciences》 4卷10期 (1988/10) Pp. 565-573

https://doi.org/10.6452/KJMS.198810.0565

摘要

本研究選擇71位系統性斑狼瘡病人和43位正常健康人為研究對象，測定其血清中之循環免疫複合體、各種補體成份和Anti-dsDNA抗體，以評估循環免疫複合體含量和臨床表徵、血液學檢查結果及疾病活動性間的關係。
本實驗以C1q-solid phase ELISA (C1q-SP)法和microtiter plate Raji Cell-ELISA (Raji Cell)法測定血清中之循環免疫複合體。可發現循環免疫複合體增加的病人比循環免疫複合體正常者，較易發生狼瘡性監炎、臉部紅斑、中神經侵犯和陽性Anti-dsDNA抗體。
以Clq-SP法所測之循環免疫複合體含量和血清中之Clq及B因子呈負相關，以Raji Cell法所測之循環免疫複合體含量和C3、C4、CH50、C3c、B因子、H因子呈負線性相關。
循環免疫複合體含量和系統性紅斑狼瘡之疾病活動性有關。活動期時循環免疫複合體顯著增加，而非活動期時則和正常人無異。
以上結果顯示，連續測定循環免疫複合體含量可用以偵測系統性紅斑狼瘡之疾病活動性的改變。

並列摘要

Circulating immune complexes (CIC) were studied in seventy-one patients with systemic lupus erythematosus (SLE) in order to correlate CIC with the clinical manifestations and the disease activity of SLE.
C1q-solid phase ELISA (C1q-SP) and microtiter plate Raji cell-ELISA (Raii cell) methods were used for measurement of CIC levels in this study. Patients with elevated CIC had a higher frequency of malar rash, CNS involvement, nephritis, and anti-dsDNA antibodies than those with normal levels of CIC.
There were negative associations between CIC detected by the C1q-SP method and C1q, and factor B; while CIC detected by the Raji cell method negatively correalated with C3, C4, CH50, C3c, factor B, and factor H. The CIC levels were well correlated with the disease activity of SLE. The more active the disease, the greater the increase of CIC.
These suggest that serial measurement of CIC is helpful in monitoring the disease activity of SLE.

並列關鍵字

circulating immune complexes ； systemic lupus erythematosus