- 期刊
Combined Cold-And Warm-Antibody Autoimmune Hemolytic Anemia - Review of the Literature and a Case Report
Waldenstrom's 巨球蛋白症合併冷性及溫性自體抗溶血性貪血－－病例報告及文獻報告整理
摘要
Waldenstroms’巨球蛋白症合併冷性及溫性自體抗體溶血性貧血在文獻上僅有一病例報告，本文報告第二病例，此病人血清中可發現免疫球蛋白G 及免疫球蛋白M之抗算體紅血球抗體。免疫球蛋白M自體抗體有廣度之抗體作用溫度範圍及抗I血球抗原特異性。免疫球蛋白G自體抗體則未具有血球抗原特異性。此病人之溶血現象須依賴類固醇才得以控制，經過化學治療及血漿置換治療後效果甚佳。自體溶血性貧血同時由冷性及溫性自體抗體引起者在臨床上相當罕見。我們同時回顧文獻上所報告的病例並描述其獨特之血清學檢查及臨床特徵。
關鍵字
無資料並列摘要
This report described the second case in the literature of waldenstrom’s macroglobulinemia with combined cold-and warm-antibody autoimmune hemolytic anemia(CCW-AIHA).Both IgG and IgM red cell auto-antibody autoimmune hemolytic anemia(auto-Abs)were present in the patient’s serum. The IgM auto-Abs had a high thermal amplitude and anti-I blood group specificity. The IgG auto-Abs did not reveal blood group specificity. This patient depended on steroids to control hemolysis, but responsed well to chemotherapy and plasmapheresis. CCW-AIHA has rarely been reported. In this study, the literature is reviewed and the characteristic serological and clinical features of this rare category of autoimmune hemolytic anemia (AIHA)are discussed.
延伸閱讀
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