Enterotoxin Effect on Hepatocytes in Experimental Intestinal Obstruction in the Rat

老鼠腸阻塞引起腸內毒素對肝細胞之影響

侯明鋒(Min-Feng Hou) ； 吳淑釧 (Shu-Chuan Wu) ； 邱秀美(Hsiu-Mei Chiu) ； 劉月娥(Yueh-Er Liu) ； 陳淑芬(Shu-Fen Chen) ； 劉文章(Wen-Jan Liu)

《The Kaohsiung Journal of Medical Sciences》 5卷10期 (1989/10) Pp. 535-539

https://doi.org/10.6452/KJMS.198910.0535

摘要

本研究是以32隻白老鼠實驗腸阻引起腸內毒素時對肝細胞之影響之實驗報告。老鼠之腸阻塞之實驗方法是以一矽質管將距小腸迴盲部10公分處將此矽質管圍繞小腸造成小腸之不完全阻塞。其阻塞時間分成三群；阻塞兩天(6隻)、四天(5隻)及七天群(5隻)，各群亦有對照組以相比較結果。
在實驗阻塞兩天，四天及七天組其腸內毒素之濃度為0.83±0.38，2.40±0.39，及10.80±2.97(M±SE)而血清中之GPT及GOT亦在阻塞第七天組為最高。經取出之肝臟以大腸內毒素染色，知道此內毒素在肝細胞沉澱染出者在Zone3為最多，經視察可知道此內毒素可染出範圍是由Zone3再擴張到Zone2及Zone1，亦可知在阻塞七天組其內毒素之沉澱範圍最廣。
由此實驗可知腸阻塞時之腸內毒素會造成肝細胞之損傷是很清楚的，所以在臨床處置腸阻塞之病患者，除了全身之變化外，其肝細胞之損傷保護，亦需要注意的。

並列摘要

Thirty-two Wistar rats were studied for liver injury caused by enterotoxemia due to experimental intestinal obstruction. In the experimental group, enterotoxin titers were measured1.83±0.38, 2.40±0.39, 10.80±2.97(M±SE) in the group of the duration of intestional obstruction for 2-,4-,and started form Zone 3 and then extended into Zone 1with prolonged obstruction. The experimental group which experienced the longest period of obstruction also exhibited elevated serum GPT and GOT levels. The severity of damage increased with time of obstruction. The disturbance of liver cells in attention in the management of intestional obstruction from this animal model.

並列關鍵字

enterotoxemia ； intestinal ； obstruction