Cardiovascular Effects of Nonivamide Succinate

Nonivamide Succinate的心臟血管作用

葉竹來(Jwu-Lai Yeh) ； 陳英俊(Ing-Jun Chen)

《The Kaohsiung Journal of Medical Sciences》 7卷4期 (1991/04) Pp. 173-182

https://doi.org/10.6452/KJMS.199104.0173

摘要

靜脈注射nonivamide或nonivamide sucinate（25,250 nmol/kg）對Wistar系大白鼠能產生心跳減緩，血壓下降及呼吸抑制作用，並引起血壓三相變化：effect A，最初血壓短暫下降；effect B，血壓回升；effect C，血壓延遲性下降反應。兩者所引起的血壓反應並不受propranolol和phentolamine的前投與所改變，對用atropine前投與的大白鼠會明顯減少effect A，而effect C會微增。最初的effect A 可受雙側迷走神經切除而消失，effect B與C卻鎮受此抑制。Noni-vamide succinate (3, 30 fmol)單側微量注射於腦內孤獨束核，產生明顯血壓，心跳下降反應。
在天竺鼠離體胸主動脈實驗裡，發現應用ninivamied或nonivamide succinate (10-8 - 10-5 M)可以減緩phenylephrine(10-6 M)對血管平滑肌的張力。然而，重覆投予則造成一種快速且持續性的迅速耐性反應。產生迅耐受性後，nonivamide及nonivamide succinate不再產生血管鬆弛作用，反而引起收縮反應。從本實驗顯示出，在投予相同劑量時，發現nonivamide succinate 的potency比nonivamide微強。

並列摘要

Intravenous injection of nonivamide or nonivamide succinate (25,250 nmol/kg) into Wistar rats induced bradycardia, hypotension, apnea and a triphasic blood pressure response: an initial short fall (effect A), an intermediate rise (effect B), and a subsequent delayed fall (effect C) of blood pressure. This blood pressure response remained unchanged after treatment with propranolol or phentolamine. In atropine-pretreatment rats the initial effect A was markedly decreased and effect C was slight increased. Effect A was absent after bilateral vagotomy.
Unilateral microinjection of nonivamide succinate (3,30 fmol) into the nucleus tractus solitarii produced a marked reduction in blood pressure and heart rate.
In the isolated aorta of the guinea pig, application of either nonivamide or its succinate (10-8 to 10-5 M) eliminated the smooth muscle tone produced by phenylephrine (10-6 M). Re-exposure to these agents, however, produced an immediate tachyphylactic relaxing response and prolonged rebound contractile response. Both compounds induced a vascular contraction rather than relaxation during tachyphylaxis. The potency of nonivamide succinate was found to be slightly greater than that of nonivamide.

並列關鍵字

capsaicin ； nonivamide succinate ； cardiovascular effects