Acetylation Phenotype in Hypertensive Patients

高血壓病患之肝臟乙醯化代謝快慢的研究

黃正一(Cheng-Yi Huang) ； 朱若愚(Jo-Yu Chu) ； 葉祖青(Tsu-Ching Yen)

《The Kaohsiung Journal of Medical Sciences》 8卷1期 (1992/01) Pp. 1-5

https://doi.org/10.6452/KJMS.199201.0001

摘要

個人對藥物代謝能力的差異可能帥因於人體基因所含酵素的不同，本研究指在探討人體因藥理，就96位到空軍總醫院心臟內科門診之高血壓病患利用服用Sulphamethazine(10 mg/kg)物六小時後測定病患肝臟之乙醯化化謝物百分比，探討其代謝速率之快慢。結果發現其中有70位屬於快速代謝者，26位屬於緩慢代謝者，此一結果可提供病患服用hydrala-zine這類藥物之危臉性評估，進而降低藥物引起紅斑性狼瘡之機率

並列摘要

Individual differences in drug-metabolizing capacity may be due to the occurrence of genetic enzyme variants. This study of pharmacogenetics in this paper explores the polymorphic acetylation of hypertensive patients who had taken hydralazine as an antihypertensive drug in the cardiovascular clinic at Chinese Air Force General Hospital. An apparent bimodal distribution of acetylator phenotype was found in 96 subjects (26 slow and 70 fast acetylators) from measuring the percentage of acetylation of sulphamethazine (SMZ) in 6-hr blood, 3-to-6 hr urine samples; and the elimination half-life (t1/2) of SMZ; after administration of SMZ 10 mg/kg. The results might provide a therapeutic index of hydralazine and reduce the probability of drug-induced lupus erythematosus.

並列關鍵字

pharmacogenetics ； sulphamethazine ； N-acetyltransferase