- 期刊
Chronic Neutrophilic Leukemia - A Case Report
慢性嗜中性球性白血病一病例報告
摘要
慢性嗜中性球性白血病是一種少見的骨髓增生性疾病，其臨床特徵常出現白血球大量升高尤其是以成熟的中性白血球為主，白血球鹼性磷酸酸活性增加，脾臟腫大，而染色體分析無費城染色體的出現；診斷上最重要的必須排除因潛在性感染或腫瘤引起的類白血症。我們報告一例慢性中性球性白血病，其中性球吞噬功能降低，經給與Hydroxyurea治療後，白血球數目漸漸恢復正常，但仍然維持高百分比的成熟中性白血球。
關鍵字
無資料並列摘要
We describe a 77-year-old patient with chronic neutrophilic leukemia (CNL). Diagnosis of CNL was made by marked increase of mature neutrophils without increased immature granulocytes, splenomegaly and elevated serum vitamin B12 level and by ruling out any infection or occult malignancy. The chromosome analysis showed one abnormal karyotype out of 14 metaphases. The neutrophilic function with nitroblue tetrazolium test revealed impaired phagocytic function in this patient. The neutrophil count became normal gradually after hydroxyurea treatment. However, it still maintained a high percentage of mature neutrophils. Background literature and the prognosis of CNL are discussed.
延伸閱讀
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