- 期刊
Effects of Corticosteroid Inhalation Therapy on Lung Ventilation and Alveolar Permeability in Asthma Using Tc-99m DTPA Radioaerosol Inhalation Lung Scintigraphy
利用Tc-99m DTPA 放射性霧氣吸入肺部閃爍造影評估皮質類固醇吸入治療對氣喘病人肺通氣及肺泡通透性的作用
摘要
本研究是針對26個氣喘病人評估其在類固醇吸入治療後，對病人的肺通氣及肺泡通透性的效用。肺通氣的均勻性是評估肺中間1/3比周邊1/3沈責吸入的放射性霧氣量的比率，本研究以分布因子（DF）表示之。肺泡通透性的損傷程度是測量放射性霧氣從左肺周邊肺泡清除的曲線，本研究以斜率表示。開始先於治療前測量一次做為基準值然後在以0.05毫克的beclomethasone dipropionate做吸入治療一天四次為期一週，治療後再測量一次以評估治療效果，結果顯示治療後肺通氣均勻度有顯著的改善（DF：0.79±0.32對0.59±0.22，P=0.0001），但肺泡通透性沒有明顯改變（斜率：1.18±0.78對1.25±0.88，P=0.052）。所得結論為皮質類固醇的治療能改善氣喘病人的肺通氣問題，但不能改變肺泡通透性。我們也建議，利用Tc-99m DTPA放射性霧氣吸入肺部閃爍造影，同時評估通氣及肺泡通透性，應該有助於了解任何影響到肺泡及通氣徑路的疾病。
關鍵字
無資料並列摘要
This study evaluates the effects of steroid inhalation on lung ventilation (LV) and alveolar permeability (AP) in 26 patients with asthma. The homogeneity of LV was evaluated as the inhalated Tc-99m diethylene triamine pentaacetic acid (DTPA) radioaerosol depositing ratios of the central 1/3 over peripheral 1/3 of the left lung. It is shown as a distribution factor (DF) in this study. The damage in AP was measured from the speed of Tc-99m DTPA radioaerosol clearance curves from the peripheral alveoli of the left lung and is represented as a slope in this study. The baseline LV and AP were calculated before an inhalation therapy of 0.05 mg beclomethasone dipropionate four times daily for one week, then the studies were repated after treatment to evaluate the effects of inhalation therapies. The results revealed a significantly improved homogeneith of LV in 16/26 (62%) case (DF: 0.79±0.32 vs 0.59±0.22, P=0.0001), but no apparent change in AP (slope: 1.18±0.78 vs 1.25±0.88, P=0.052) after the treatment. In conclusion, a corticosteroid inhalation therapy for asthma can improve the peripheral LV, but can not change the AP according to the findings of Tc-99m DTPA radioaerosol inhalation lung scintigraphy. We suggest that the widely available Tc-99m DTPA radioaerosol inhalation lung scintigraphy, couple with the evaluation of LV and AP could contribute to any disorder involving both alveoli and airways.
延伸閱讀
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- 林佳慧、吳美靜、施志宏、洪弘昌（2018）。【論文摘要】流感後肺纖維化病患使用經鼻高流量氧氣之呼吸照護經驗。呼吸治療，17(1)，83-83。https://doi.org/10.6269/JRT.201807_17(1).0049
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