The Ultrastructural Study on Epithelium of Gallbladder with Gallstones

膽囊結石症之膽囊上皮細胞微細構造之研究

李金德(King-Teh Lee) ； 沈柏青(Pai-Ching Sheen)

《The Kaohsiung Journal of Medical Sciences》 12卷1期 (1996/01) Pp. 7-11

https://doi.org/10.6452/KJMS.199601.0007

摘要

為了闡明各種不同膽囊結石症之膽囊上皮細胞微細構造，我們以10例膽固醇結石膽囊及10例膽色素結石膽囊進行電子顯微鏡觀察它們的膽囊上皮細胞試圖去探討不同種類的膽囊結石是否會有不同的上皮細胞微細構造，並且與10例對照組的膽囊比較。結果我們發現，除了膽固醇結石的膽囊上皮細胞含有半月狀的構造（crescent structure）外，這三種類的膽囊上皮細胞微細構造都非常相似。它們都是長柱狀的細胞，細胞的游離面有絨毛（microvilli）；細胞內含有相當多的粘液小滴（mucous droplet）、高氏體（Golgi apparatus）、粗面內質網（rough endoplasmic reticulum）及粒線體（mitochondria）都很發達；並且可以見到很多的多泡緻密體（multivesicular dense body）。只有一些含結石的膽囊上皮細胞變得較扁平，絨毛也較短。由上述的觀察，我們認為膽囊上皮細胞是粘液分泌很旺盛的上皮細胞；藉著分泌多量的粘液，膽囊在結石形成上也佔了重要角色。

並列摘要

To investigate the fine structures of epithelium, 30 patients bearing gallstones were subjects for this study: ten for gallbladders with cholesterol stones, 10 for pigment stones and 10 for the control. The electron microscopic examination of these specimens revealed that all the epithelial cells from three gallbladder models had similar ultrastructural features. The most striking feature was the presence of numerous mucous droplets in the apical portion of the all epithelial cell. Another prominent finding was multivesicular bodies predominantly in gallbladders with pigment stone. golgi apparatus, rough endoplasmic reticulum and mitochondria were apparent and well-developed. Crescent and semi-circular structures were found exclusively in gallbladders with cholesterol gallstones.

並列關鍵字

gallstone ； gallbladder ； ultrastructure