Comparison of Intravenous Granisetron with Metoclopramide Plus Dexamethasone in the Prevention of Nausea and Vomiting Associated with Emetogenic Cytotoxic Chemotherapy

本研究主要目的在評估與比較一個新的5-HT3拮抗劑，Granisetron，和目前所使用的標準止吐劑，Metoclopramide加上Dexamethasone在對於第一次接受化學治療的腫瘤病人所引起的噁心嘔吐的預防效果。結果顯示在化學治療後第一天噁心嘔吐的預防效果於Granisetron治療組與Metoclopramide加上Dexamethasone的控制組分別為84%與95%；而在往後六天的效果則為77%與60%，兩組結果無顯著差別。而在藥物副作用上，Granisetron治療沮則比Metoclopramide加上Dexamethasone的控制組較少且無椎體外症候群。因此我們結論，以單一劑量3mg的Granisetron來預防化學治療引起的噁心嘔吐與傳統Metoclopramide加上Dexamethasone具有同等的效果且副作用較少，Granisetron單一劑量是一種簡便有效的預防化學治療引起的噁心嘔吐方法。

關鍵字

無資料

並列摘要

Fifty-one patients who received their first course of chemotherapy were studied to compare the respective efficacy and safety of granisetron and metoclopramide plus dexamethasone in the prevention of nausea and vomiting induced by emetogenic cytotoxic drugs. The results showed the response rate of antiemesis in the first 24 hours was higher in the metoclopramide plus dexamethasone group than in the granisetron group: 95% vs 84%. For the next six days of the study period, the response rate of the granisetron group was shown to be more effective than that of metoclopramide plus dexamethasone group: 77% vs 60%. Furthermore, the granisetron seemed to display enhanced tolerability with less drug-related side effects and no extrapyramidal effects which appeared in 2 cases of the metoclopramide plus dexamethasone group. In conclusion, a single dose of granisetron can be as effective as the gold standard of metoclopramide plus dexamethasone regimen in preventing and treating acute nausea and vomiting. For preventing delayed nausea and vomiting, granisetron is shown to be more effective than metoclopramide plus dexamethasone.

並列關鍵字

granisetron ； antiemetic ； chemotherapy

國際替代計量

Comparison of Intravenous Granisetron with Metoclopramide Plus Dexamethasone in the Prevention of Nausea and Vomiting Associated with Emetogenic Cytotoxic Chemotherapy

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