- 期刊
Tissue Polypeptide Antigen, Carcinoembryonic Antigen, Carbohydrate Antigen, and CA125 Levels as Tumor Markers in Squamous Cell Carcinoma of the Head and Neck
頭頸部腫瘤之扁平上皮細胞癌以TPA,CEA,CA19-9及CA 125做為腫瘤標幟之表現
摘要
98名未接受過治療的頭頸部上皮癌病人，其中包含喉癌36名，口腔癌48名，鼻癌14名，以TPA, CEA, CA19-9及CA 125做為腫瘤標幟來檢測其治療前後之表現。另外50名健康個人及42名患耳鼻喉良性病灶之病人，被當為正常及疾病的控制組。喉癌病人中，TPA, CEA, CA19-9及CA之陽性率分別為22.3％，27.8％，5.6％，及0％。喉癌晚期病人的TPA值比早期者呈有意義的增高；相反地，CEA值在早期病人則較高。口腔癌病人中 陽性率分別為TPA（25.0％）,CEA（18.8％）,CA19-9（14.6％）及CA125（4.2％）；而且，其腫瘤標幟值與口腔癌分期並無相關。腫瘤標幟對於鼻癌則似乎一點都無用處。以喉癌及口腔癌合併討論，則腫塊與淋巴腺大小和各種的腫瘤標幟值並無相關。僅有喉癌，其TPA值在治療前有上升者，其治療後呈有意義下降。總而言之，僅TPA人CEA標幟在頭頸部癌症中，有某種程度的意義。
關鍵字
無資料並列摘要
Ninety-eight untreated patients with squamous cell carcinoma of the head and neek of different localizations (larynx 36, oral cavity 48, nasal cavity 14) were selected for a study to measure TPA, CEA, CA 19-9, CA125 pre- and post-therapy. Fifty healthy individuals and 42patients with benign lesions were as normal and disease controls. The positive rates were 22.3%, 27.8%, 5.6% and 0% respectively in TPA, CEA, CA19-9 and CA125 markers in laryngeal cancer patients. The positive rates of TPA level was higher with significant difference in advanced stage group than in early stage group; conversely, the positive rage of CEA levels were somewhat high in early stages of laryngeal cancer. Meanwhile, the positive rates were 25.0%, 18.8%, 14.6% and 4.2% individually in the same order in oral cancer patients. There was no relationship between the marker levels and progression of the oral cancer. The tumor markers were almost of no use in detecting nasal cancer. It also seemed there was no relationship between the various serum levels and the tumor or nodal burden in laryngeal and oral cancer. Only TPA level decreased significantly after therapy in patients with laryngeal and oral cancer who had originally elevated marker levels. Conclusively, only TPA and CEA markers are of some clinical use in the disease.
延伸閱讀
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