An Abnormal Cholesterol Profile in Young Adults with Normocholesterolemic Cerebral Ischemia

在正常血中膽固醇濃度下,其膽固醇在脂白蛋的分佈有可能異常，這種情形亦足以導脂肪性傷害。至今，所有對非心臟性腦缺血中風之相關研究，在年輕亞洲人少被提及。本文是研究脂白蛋中膽固醇在年輕台灣缺血腦中風病患，若果血中膽固醇濃度少於250 mg%下，其分佈情形。結果顯示在血中膽固醇濃度下少於200 mg%之病患，膽固醇異常是高密度脂白膽固醇下降合併非常低密度脂蛋白膽固醇上升；而大於200 mg%之病患，則只有高密度脂蛋白膽固醇下降。膽固醇對脂蛋白上膽固醇分佈，及在不同脂蛋白上膽固醇互相之控制亦異常。這些結果應與病患本身之危險因子無關係。因此，對血中膽固醇濃度正常之年輕非心臟性腦缺血性中風病患，我們建議應予以詳細檢查其膽固醇之分佈。對飲食，生活及藥物亦應予以適當調整及安排。

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並列摘要

An abnormal cholesterol fraction can still he able to provoke cascades of lipidic atherogenesis even when the serum TC level is within normal range(＜ 200 mg%). However, there is a shortage of convincing data concerning cerebral atherogenesis in young Asians who have a different diet habit and living style from those in western countries. In this study, we examined the lipoprotein-cholesterol profile in young Taiwanese patients with noncardiac cerebral ischemia (NCCI) whose serum TC level was ＜ 200 mg% and 200 – 200 mg%250 mg%. The results showed a decrease of HDLC and an increase of VLDLC in patients with TC ＜ 200 mg%, but only a decrease of HDLC in patients with TC =200 – 250 mg%. The cholesterol fraction metabolism is obviously perplexed in NCCI subjects. These findings were not related to their associated risk factors. Accordingly, a derange ment of cl1o1esterol fraction with normal serum TC level can also incite lipidic cerebral atherogenesis in young Taiwanese adults. Therefore, a detailed evaluation of cholesterol profile should be born in mind in young eastern NCCI patients despite of a normal serum TC level. Tailored measure of diet and living should be modified to prevent lipidic atherognesis in our society in future.

並列關鍵字

cholesterol；cerebral ischemia；young

國際替代計量

An Abnormal Cholesterol Profile in Young Adults with Normocholesterolemic Cerebral Ischemia

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