Monocyte-Derived Cytokine -IL-12,TGF-β1 and  TNF-α in Patients with Tuberculosis

結核病是由結核枓桿菌所導致的一種很重要的傳染性疾病，由於人類對結核桿菌所誘發的免疫反應以及細胞激素的分泌有所不同，其傳染後的結果就有相當大的差異。本研究則是以結核病人與長期接觸結核病人，但從未發病之醫療人員為研究對象，利用各種不同的結核菌抗原去刺激血液中單核球，再以免疫酵素分析法去測定各種單核球所分泌的細胞激素。我們發現，正常人的單核球在沒有任何抗原的刺激下分泌較多的IL-12，但在結核菌抗原的刺激下，病人組分泌較多的IL-12以及TNF-α，並且在兩組對象其細胞激素間的配對分泌也呈現不同的典型。故本研究顯示，正常人與結核病人其單核球對結核菌的免疫反應是不同的。

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並列摘要

Pulmonary tuberculosis is an infectious disease caused by Mycobacterium tuberculosis (MTB). This microorganism is capable of inducing a delayed hypersensitivity in the lung, with subsequent expression of the disease. This reaction depends on the presence of different cytokines that exert specific functions. To study the variability of different cytokine responses after MTB antigenic challenge, we used antigens derived from MTB to stimulate the monocytes from both normal healthy contact and the patients with active tuberculosis. We found in the resting state monocytes from healthy contact secreted higher amounts of IL-12 than those from patients. After stimulation with MTB antigen, the secretion of IL-12 did not increase in normal healthy contact, but in patients with tuberculosis the secretion increased. After MTB antigen stimulation, monocytes from patients with active tuberculosis secreted a higher amount of TNF-α. In summary, the patterns of monocyte-derived cytokine secretion upon mycobacterial antigen challenge were different in these two groups.

並列關鍵字

monocyte；tuberculosis；interleukin 12；tumor necrosis factor-α；transforming growth factor-β1

國際替代計量

Monocyte-Derived Cytokine -IL-12,TGF-β1 and TNF-α in Patients with Tuberculosis

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