[GD(DTPA-BDMA)] as a Magnetic Resonance Contrast Agent: Acute Toxicity Test and Preliminary Images

磁振造影對比劑[Gd(DTPA-BDMA)]：急性毒性試驗與初步磁振造影術之評估

許瑞昇(Reu-Sheng Sheu) ； 王雲銘(Yun-Ming Wang) ； 郭禹廷(Yu-Ting Kuo) ； 鄭粲煌(Tsann-Hwang Cheng) ； 趙垂勳(Twei-Shiun Jaw) ； 劉金昌(Gin-Chung Liu)

《The Kaohsiung Journal of Medical Sciences》 18卷2期 (2002/02) Pp. 77-83

https://doi.org/10.6452/KJMS.200202.0077

摘要

Gd-1,7-bis[(N,dimethyl(carbomyol) methyl)-1,4,7-triazaheptane-1,4,7-triacetate [Gd(DTPA-BDMA)]是一種新合成的非離子性磁振造影對比劑。[Gd(DTPA-BDMA)]的R1弛緩率為4.13 ±0.2 mM-1S-1與[Gd(DTPA)]2- (4.08 mM-1S-1)(Magnevist , Shering AG, Berlin, Germany)相近。本研究目的在於了解[Gd(DTPA-BDMA)]的急性毒性（半致死劑量）與磁振造影術顯影的特性。結果發現代表急性毒性之半致死劑量[Gd(DTPA-BDMA)]為10.58 mmol/kg高於[Gd(DTPA)]2-之6.40 mmol/kg。動物磁振造影術研究發現不論是對照組或CHA(Cheng hepatoma ascites, AS 30-D)腫瘤動物模型，[Gd(DTPA-BDMA)]與[Gd(DTPA)]2-顯影效果與排除途徑皆相似。顯示[Gd(DTPA-BDMA)]為一具有潛力的細胞外磁振造影對比劑。

並列摘要

The new complex of Gd(III) with the 1,7-bis[(N-dimethyl(carbomoyl)methyl)-1,4,7-triazaheptane-1,4,7-triacetate [Gd(DTPA-BDMA)] is a non-ionic paramagnetic complex designed for use as an extracellular magnetic resonance imaging (MRI) contrast agent. The R1 relaxivity value of [Gd(DTPA-BDMA)] is 4.13 ±0.2 mM-1S-1, which is similar to that of [Gd(DTPA)]2- (4.08 mM-1S-1). The purpose of this study is to examine the acute toxicity and MRI characteristics of [Gd(DTPA-BDMA)]. Our results show that the lethal dose (LD50) of the [Gd(DTPA-BDMA)] is 10.58 mmol/kg in ICR mice, which is higher than that of [Gd(DTPA)]2-(6.40 mmol/kg). The MR images demonstrate that the enhancing effect and renal clearance of [Gd(DTPA-BDMA)] are similar to that of [Gd(DTPA)]2- either in control group or CHA (Cheng hepatoma ascites) tumor model in Wistar rats (p ＞ 0.05). These findings indicate that [(DTPA-BDMA)] has similar characteristics of [Gd(DTPA)]2- and has the potential of becoming a safe and reliable magnetopharmaceutical for the extracellular MRI contrast agent.

並列關鍵字

magnetic resonance imaging ； contrast media ； [Gd(DTPA-BDMA)]