- 期刊
Combined Interferon-α and Inosiplex Treatment of Subacute Sclerosing Panencephalitis: A Case Report
亞急性結節性泛腦炎合併腦室內注射甲型干擾素及口服 Inosiplex 治療 － 病例報告
摘要
本文為一位15歲男孩罹患亞急性結節性泛腦炎（SSPE）之病例報告。患者在住院後，經由臨床表現、腦波、脊椎液分析與腦組織病理等檢查確認診斷。最初的臨床表現，為在校成績減退與人格改變，而後八個月內漸進式肌躍症不自主的運動、智能障礙，並迅速持續退化。在給與患者口服inosiplex與腦室注射干擾素後，病情終於慢慢穩定，且神經失能指數（NDI）有上升的現象。在治療期間除了開始時有持續數天的體溫升高外，並沒有其他嚴重的副作用發生。口服inosiplex與腦室注射干擾素合併使用為一安全及有效的療法。疾病的早期發現與積極治療應該被強調與重視。
並列摘要
Subacute sclerosing panencephalitis (SSPE) is rare in Taiwan. On admission to hospital, a 15-year-old boy was diagnosed with SSPE based on the clinical picture, electroencephalogram, cerebrospinal fluid studies, and brain biopsy. The initial clinical picture was a decline in school performance and a change in personality, followed by progressive tic-like involuntary movements and mental impairment for 8 months, then a rapidly progressive course. After the patient was treated with oral inosiplex and intraventricular interferon-α(IFN-α), his condition stabilized and the neurologic disability index score improved slightly. There were no major side effects during treatment except for a transient initial elevation of body temperature that lasted for several days. Oral inosiplex and intraventricular IFN-α appear to be safe and effective. Early identification and aggressive treatment of SSPE is important.
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