Computerized Morphometric Study of Thyroid Follicular Carcinoma in Correlation with Known Prognostic Factors

甲狀腺濾泡細胞癌之電腦輔助形態測定研究與預後因子之關係

王勝嵐(Sheng-Lan Wang) ； 陳漢文(Hon-Man Chan) ； 楊曉芳(Sheau-Fang Yang) ； 吳明蒼(Ming-Tsang Wu) ； 蔡志仁(Chee-Yin Chai)

《The Kaohsiung Journal of Medical Sciences》 21卷2期 (2005/02) Pp. 65-69

摘要

本研究主要探討在甲狀腺濾泡細胞癌中腫瘤細胞之電腦輔助形態測定研究與預後因子之關聯性。36例甲狀腺濾泡細胞癌依據病人性別、年紀、腫瘤大小、是否有血管侵犯與是否有遠處轉移這些傳統上臨床使用的預後因子來分組。先利用數位顯微照相系統隨意選取至少100個細胞核，同時選定細胞核之面積大小、周長、最大徑與最小徑比、細胞核面積之變異係數當作形態測定研究的變數，利用電腦輔助程式計算出每個病例相對應的變數值再與不同預後因子之組別分別做統計上的分析。我們的研究結果並未顯示不同預後因子之組別與選定的形態測定研究的變數之關聯性有統計上的意義。因此我們認為，電腦輔助形態測定研究法並不適合用來評估甲狀腺濾泡細胞癌的預後情形。

關鍵字

形態測定法 ； 瀘泡細胞癌 ； 預後因子

並列摘要

This study investigates the correlation between computer-assisted nuclear morphometry and known prognostic factors in thyroid follicular carcinoma. Thirty-six patients with thyroid follicular carcinoma who underwent surgery between 1991 and 2001 were grouped according to sex, age, size of the primary lesion, the presence of vascular invasion, and metastases. Four nuclear parameters were measured and analyzed: mean nuclear area, mean nuclear perimeter, largest to smallest diameter ratio of the nuclei, and coefficient of variation of the nuclear area. Our results indicated that none of the chosen nuclear variables were significantly correlated with the prognostic factors studied. In conclusion, nuclear morphometry does not seem to correlate with known prognostic factors and cannot serve as an additional predicting factor for biologic behavior.

並列關鍵字

morphometry ； follicular carcinoma ； prognostic factor