- 期刊
Primary Pulmonary Synovial sarcoma: A Case Report
原發性肺滑液肉瘤－病例報告
摘要
原發性肺滑液肉瘤是一種相當罕見之肺部腫瘤，迄今，僅有數十例零星發表的個案。本文報告一名57歲男性在例行的胸部X光檢查在右肺意外地發現一顆約4.5公分大的腫瘤。經實行肺右中葉切除手術後，由病理檢查及免疫組識化學染色檢查得知結果為滑液肉瘤，且經過反轉錄酶聚合鏈反應的產物確認結果無誤。本文除病例報告外，同時探討其臨床、組識、免疫組識化學染色及分子檢查的表現。
並列摘要
We report a rare case of primary synovial sarcoma of the lung. A 57-year-old man had a welldefined tumor in the right middle lobe seen on chest computed tomography, and underwent lobectomy. Grossly, the nonencapsulated tumor measured 4.5 cm in greatest diameter, with a solid and tan-white cut surface. Histologically, the tumor was mainly composed of a dense proliferation of spindle cells. Immunohistochemical studies were focally positive for epithelial membrane antigen, and diffusely positive for CD99 and Bcl-2. Cytokeratin, S-100 protein, desmin, smooth muscle actin, and CD34 were absent. SYT-SSX1 gene fusion transcript was detected by reverse transcription–polymerase chain reaction, which is diagnostic of primary synovial sarcoma of the lung. We also review the literature with regard to the clinicopathologic, immunohistochemical, and molecular studies of primary pulmonary synovial sarcoma.
延伸閱讀
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