This article discusses the nursing care experience in a 77-year-old male patient. He suffered from right Total Knee Arthroplasty septic loosening after the resection arthroplasty and received the operation in our hospital after the infection was under control. We used the Gordon 11 Functional Health Patterns scale to estimate the patient's healthy function, by revealing the major problems such as existing infection, pain, physical immobility, and lacking knowledge of the specific disease. During the nursing process, guided by pre-operation instruction, we listened to the feeling of patients. Our goal was to prevent post operation infection and provide individual nursing instruction to preserve the patient's limb mobility. Through this experience, the orthopedic nursing staff may learn more deeply about the caring revision of the arthroplasty patients. It is hoped that more effective nursing instructions can be made in this future.