This article describes our experience of using self-efficacy theory to care for a patient who underwent total knee replacement. The nursing period was October 5 to 12, 2020. Observation, physical assessment, and interviews were conducted to collect data for major nursing assessments. Three major health problems were noted: acute pain, impaired physical mobility, and anxiety. Our medical team designed a care plan with the patient and their family. This plan focused on providing pain relief, home-based care and rehabilitation, and a safe home environment to facilitate patient participation in rehabilitation programs and reduce their anxiety. During follow-up, home visits and telephone interviews were conducted to evaluate the patient's self-efficacy and encourage the patient to maintain self-care. Our findings may guide clinical nursing care for patients undergoing total knee replacement.