A transdisciplinary care model of evidence-based practice (EBP) has currently become the most important clinical care model. Single disciplinary approach could not provide a ”patient-centered care” as well as the holistic comprehensive care. Based on a transdisciplinary care model of evidence-based practice, different professionals can realize the value of collaboration and make the best clinical decision through efficient communication, and achieve better quality care for patients. In this article, we discussed the reasons and definition regarding transdisciplinary care model of evidence-based practice and integrated relevant literatures of strategies for development of transdisciplinary practices. We anticipate providing references for clinical practitioners and policy makers of clinics, helping nursing professionals and other disciplines to recognize ways to engage in transdisciplinary care of evidence-based practice and to apply it in clinical practices.