Hypothermia therapy is currently the most effective treatment for hypoxic-ischemic encephalopathy caused by asphyxia in the perinatal period. It has been revealed to reduce neonatal mortality; alleviate moderate to severe neurological disability, severe cerebral palsy, and intellectual disabilities; and improve cognitive function. The earlier the therapy is commenced, the stronger the effect of neuroprotection. Nursing departments play a crucial role in hypothermia treatment. In addition to understanding the risks of hypothermia treatment, these departments also must understand the importance of monitoring and supporting the family, and help to reduce the complications associated with hypothermia treatment. Therefore, nursing departments must have the ability to perform hypothermia treatment. By sharing our clinical experience with hypothermia therapy, we hope to improve the quality of nursing care.