This paper describes a nurse's experience caring for a 73-year-old female patient with liver cirrhosis, ascites, and hepatic encephalopathy, in the face of physical, psychological, and social changes, from June 19 to July 30, 2020. Data on the patient's physical, mental, and social statuses were collected and a holistic assessment was performed based on Gordon's 11 Functional Health Patterns. The main health problems were excessive body fluid volume, acute confusion, and insufficient response capacity. Effective nursing strategies, individualized care, and contact with professional medical teams can improve the patient's health and quality of life after discharge. To achieve the care of the whole person, the whole team, the whole process, the whole family and the whole community. This case study can provide a reference for nurses caring for patients with liver cirrhosis.