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Hypothyroidism and Lipid Metabolism in Several Rat Tissues

甲狀腺功能減退與大白鼠若干組織之脂類代謝

摘要


切除大白鼠甲狀腺後研究其若干組織中之脂類代謝,但由於切除不够完全,泰半大白鼠僅能稱為甲狀腺功能減退。大白鼠經首次手術後,分別予以相當時間之觀察,或再進行次一步之手術;則見甲狀腺切除兼有下視丘破壞之大白鼠,受T3處理後,其脂肪組織中脂類之改變,為體重減輕之主;而高熱量食物塡飼切除甲狀腺之大白鼠,促使肝臓聚集大量肝醣,及圍腎脂肪中總脂及三酸甘油脂各含量降低。

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並列摘要


Hsu, C., G. W. Wang, H. K. Li and A. C. Liu. Hypothyroidism and lipid metabolism in some rat tissues, Chinese J.Physiol.,20(1):33-43,1967.-A study was made on thyroidectomy(TE)and lipid metabolism in several rat tissues. Due to incomplete removal, the rats in most of the cases were in hypothyroid state. Enough time after the first operation was allowed before an observation or a further operation was done. Triiodothyronine(T3)treatment of TE rat with hypothalamic lesioning(HL)reduced the body weight mainly from the adipose tissue fat while force-feeding(F)in TE rat led to glycogen accumulation in the liver with some reduction of total lipid and triglyceride in the perirenal fat.

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