Effect of Some Vitamins on Resistance to Hypoxia in Mice

數種維生素對於小白鼠抵抗缺氧能力之影響

郭雅惠(Y. F. Kuo) ； 方懷時(H. S. Fang)

《The Chinese Journal of Physiology》 20卷1期 (1967/06) Pp. 79-82

摘要

讓動物在低壓室內經受缺氧，藉「高空痙攣」之症狀作指標，測定數種維生素對於小白鼠抵抗缺氧能力之影響。實驗之結果，顯示核黃素，菸草酸及維生素丙，均對缺氧之耐受能力無影響，而菸草醯胺則可增强小白鼠對於缺氧之耐受能力。腹腔內注射適量生理鹽水之小白鼠（對照組），平均在39,800呎之高度呈高空痙攣，但腹腔內注射菸草醯胺之小白鼠（實驗組），平均在42,000呎之高度呈高空痉攣，何以有此現象，曾加以討論。
遭受嚴重之缺氧時，約有三分之一之小白鼠，每引起排便，其可能原因，亦曾討論。

並列摘要

Y. F. Kuo and H. S. Fang. Effect of some vitamins on resistance to hypoxia in mice. Chinese J.Physiol.,20(1):79-82,1967.-The effect of some vitamins was studied on the hypoxic tolerance in mice. Essentially altitude convulsion threshold was taken for determining the resistance to hypoxia. It was found that riboflavin, ascorbic acid and niacin had no anti-hypoxic effect. Niacinamide caused a significant decrease in altitude convulsion threshold. Mice treated with niacinamide did not convulse until they had reached a barometric pressure of 128 mm-Hg(simulated altitude of 42,000 feet),while untreated controls went into convulsion at an average pressure of 142mm-Hg(39,800 feet).The possible mechanism of such an increase in hypoxic tolerance was discussed.