- 期刊
Effect of Naloxone on Platelet Aggregation in Rats
並列摘要
The effect of naloxone on aggregation of blood platelets was investigated. Naloxone in millimolar concentrations dose-dependently inhibited collagen (20 μg/ml)-induced platelet aggregation in rats PRP. For comparison with IC50 values on a molar basis, the ability of naloxone against platelet aggregation is similar to aspirin, but about 7-8 fold smaller than verapamil. In anesthetized spontaneouly hypertensive rats (SHR), naloxone did not significantly alter the pressure response whereas administration of prazosin caused diminution of mean arterial pressure (MAP) related to dose. Naloxone did not interfere with the hematological parameters (i.e., WBC, RBC, PLT, HGB, HCT...etc.) in Sprague-Dawley (SD) rats. The present study shows naloxone to be effective in obviating platelet aggregation, and seems to be reasonable in prevention of pulmonary platelet trapping (PPT), which is thought to play an important role in the pathogenesis of adult respiratory distress syndrome (ARDS).
延伸閱讀
- 張進芳（2014）。H1 Receptor Antagonist and Initiation of Flap Necrosis in Vascular Anastomosis in Rats〔碩士論文，中山醫學大學〕。華藝線上圖書館。https://doi.org/10.6834/CSMU.2014.00114
- Poon, Y. K. (1989). The antagonistic effect of paracetamol on ethanol-induced gastric damage in rats [master's thesis, The University of Hong Kong]. Airiti Library. https://www.airitilibrary.com/Article/Detail?DocID=U0029-1812201200005245
- Que, J., Lin, L. C., Liu, S. Y., Chu, C. C., Liu, K. S., Ho, S. T., & Wang, J. J. (2005). A Novel Long-acting Analgesic: Buprenorphine Palmitate in Rats. Acta Anaesthesiologica Taiwanica, 43(1), 11-16. https://www.airitilibrary.com/Article/Detail?DocID=02541319-200503-43-1-11-16-a
- Huang, W. C., Lee, R. S., & Young, T. K. (1974). Depletion of Neurohypophysial Vasopressin Content in Rats Following Hemorrhage. The Chinese Journal of Physiology, 21(4), 237-243. https://www.airitilibrary.com/Article/Detail?DocID=03044920-197412-21-4-237-243-a
- Lin, Y. W., Yeh, L. S., Hou, S. M., & Lin, C. T. (2002). Apoptosis and Graft Rejection in Rat Composite Tissue Allotransplantation. Journal of Orthopaedic Surgery Taiwan, 19(3), 127-130. https://www.airitilibrary.com/Article/Detail?DocID=10116923-200209-19-3-127-130-a