- 期刊
Quantifying Operant Behavior Deficits in Rats with Bilateral 6-Hydroxydopamine Lesions of the Ventrolateral Striatum
並列摘要
Both age and sex influence vascular contractile functions and play significant roles in cardiovascularregulation.Recent research has focused on the action of sex steroids on blood vessels and characterizedboth endothelium-dependent as well as -independent effects in agonists-induced contractile response.However,to study the combined influences of age and sex steroids present a complicated situation.Inthe current investigation,we studied the role of both these physiological factors in an in vitro approach.We found that high concentrations of estrogen(E2,17β-estradiol)significantly inhibited contractileresponse induced by KCl in endothelium-denuded aorta derived from both young(24 wk)and aged(53wk)male rats.The contractile responses in aorta from aged rats were significantly less than that fromyoung adults in the absence or presence of E2 indicating that the vascular effect of E2 could bedemonstrated in both young and aged male rats.Taken together,our data suggest that E2's action onendothelium-independent,KCl-induced contractile response in vitro could serve as a simple modelsystem to examine the interaction of aging process and gender difference on vascular functions.
延伸閱讀
- Pi, W. P. (1990). Effects of Biogenic Amine Precursors on Ovarian Steroid-Induced LH Release in Acutely Ovariectomized Rats. The Chinese Journal of Physiology, 33(4), 335-343. https://www.airitilibrary.com/Article/Detail?DocID=03044920-199012-33-4-335-343-a
- Hsieh, M. T., Peng, W. H., & Hsieh, C. C. (1994). Effects of DL-Tetrahydropalmatine on Motor Activity and the Brain Monoamine Concentration in Rats. The Chinese Journal of Physiology, 37(2), 79-82. https://www.airitilibrary.com/Article/Detail?DocID=03044920-199406-37-2-79-82-a
- Morgan, M. M., Ashley, M. D., Ingram, S. L., & Christie, M. J. (2009). Behavioral Consequences of Delta-Opioid Receptor Activation in the Periaqueductal Gray of Morphine Tolerant Rats. Neural Plasticity, 2009(), 94-100. https://doi.org/10.1155/2009/516328
- Malekabadi, H. A., Hosseini, M., Pourganji, M., Zabihi, H., Saeedjalali, M., & Anaeigoudari, A. (2015). Deletion of Ovarian Hormones Induces a Sickness Behavior in Rats Comparable to the Effect of Lipopolysaccharide. Neurology Research International, 2015(), 119-129. https://doi.org/10.1155/2015/627642
- Li, H. K., Chang, L. R., & Young, T. K. (1969). Depletion of Neurohypophysial Hormones in the Pituitary of Alloxan Diabetic Rats. The Chinese Journal of Physiology, 20(3), 229-233. https://www.airitilibrary.com/Article/Detail?DocID=03044920-196912-20-3-229-233-a