- 期刊
Spike Responses of Sympathetic Vertebral Nerve Activities during Stimulation of the Pressor Dorsomedial and Rostral Ventrolateral Medulla Differ in Cats
並列摘要
In this study, we developed a differential integrator unit containing a window discriminator (WPI121) and three integrators (sample/hold, Gould) to characterize the difference in spikes involved in sympathetic vertebral nerve activity (VNA) and integrated VNA (Int. VNA) during stimulation of the dorsomedial (DM) and rostral ventrolateral (RVLM) medulla. The upper level (UL) in the window discriminator was set at a value, 80% of the VNA amplitude above the zero. The low level (EL) was set at a value 10% above the zero. The number of VNA spikes above the UL in the window discriminator was defined as Fa, while the number of VNA spikes within the UL and EL as Fw. In 26 cats anesthetized with urethane and α-chloralose, results showed that electrical stimulation and microinjections of glutamate (Glu, 0.25M, 50n1) or glycine (Gly, 1.0M, 50n1) at the same point in DM or RVLM increased both systemic arterial pressure (SAP) and Int. VNA. However, the increase of Int. VNA on DM stimulation was contributed by increases of both Fa and Fw, while on RVLM stimulation the increase of Int.VNA was mainly contributed by the increase of Fa, against a decrease of Fw. As compared to Glu, stimulation of DM by Gly produced more increase in Fw, while stimulation of RVLM by Gly produced more decrease in Fw. During RVLM stimulation the VNA was usually transferred to a huge synchronized oscillation. These findings suggest that although stimulations of the sympathetic-pressor neurons in UM and RVLM produce similar increases in SAP and VNA, the nature of these neurons is different.
延伸閱讀
- Fung, M. L., Liaw, J. M., & Hwang, J. C. (1989). Effect of Electrical Stimulation of the Superior Laryngeal Nerve on Respiratory-Modulated Facial Nerve Activity in Cats. The Chinese Journal of Physiology, 32(2), 81-91. https://www.airitilibrary.com/Article/Detail?DocID=03044920-198912-32-2-81-91-a
- Kuo, C. C., Lee, J. C., Chiou, R. J., Tsai, M. L., & Yen, C. T. (2013). Spatiotemporal Changes of Neuronal Responses in the Primary Somatosensory Cortex to Noxious Tail Stimulation in Awake and Pentobarbital-Anesthetized Rats. The Chinese Journal of Physiology, (), 1-11. https://doi.org/10.4077/CJP.2015.BAD291
- Kuo, C. C., Lee, J. C., Chiou, R. J., Tsai, M. L., & Yen, C. T. (2015). Spatiotemporal Changes of Neuronal Responses in the Primary Somatosensory Cortex to Noxious Tail Stimulation in Awake and Pentobarbital-Anesthetized Rats. The Chinese Journal of Physiology, 58(5), 332-342. https://doi.org/10.4077/CJP.2015.BAD291
- Cheng, C. C., Tung, K. C., Fu, Y. C., Gong, C. L., Chen, Y. T., Lin, N. N., Lin, J. A., & Chiu, Y. T. (2008). Activated Matrix Metalloproteinase and Disrupted Myocardial Collagen Matrix in Increased Sympathetic Activity Following Stimulation of Dorsal Medulla in the Vagotomized Feline Model. The Chinese Journal of Physiology, 51(1), 7-12. https://www.airitilibrary.com/Article/Detail?DocID=03044920-200802-51-1-7-12-a
- Chen, S. Y., & Chai, C. Y. (1999). Non-NMDA Receptors Mediate both Pressor and Depressor Actions of the Cardiovascular-Reactive Areas in the Brainstem of Cats. The Chinese Journal of Physiology, 42(2), 95-101. https://www.airitilibrary.com/Article/Detail?DocID=03044920-199906-42-2-95-101-a