Effects of L-Glutamic Acid on Acid Secretion and Mucosal Blood Flow in the Rat Stomach

Li Hsueh Tsai ； Lih Ron Huang ； Sheng-Hhsuan Chen ； Hung-Jung Liu ； Liang-Shung Chou

《The Chinese Journal of Physiology》 42卷3期 (1999/09) Pp. 181-187

並列摘要

The effect of intravenous administration of L-glutamic acid (L-Glu) on gastric acid secretion and gastric mucosal blood flow (GMBF) in anesthetized rats were investigated. Infusion with synthetic L-Glu alone had no effect on spontaneous acid secretion. However, L-Glu reduced histamine-(2 mg/kg/hr) or oxotremorine-(1μg/kg/hr) stimulated acid secretion, whereas L-Glu had no effect on acid secretion induced by pentagastrin (8μg/kg/hr). Furthermore, this inhibitory effect of L-Glu on histamine-or oxotremorine-stimulated acid secretion was blocked by 6,7-dinitroquinoxaline-2,3-dione (DNQX), a non-NMDA receptor antagonist. The effect of L-Glu on gastric mucosal microcirculation in the anesthetized rats was evaluated by using Laser Doppler Flowmetry (LDF). The results showed that L-Glu did not significantly reduce both mucosal and serosal blood flow in stomach. No significant modulatory effect on histamine- or oxotremorine-stimulated increase in GMBF was noted after infusion with L-Glu. It is concluded that L-glutamic acid is capable of the modulating of gastric acid secretion via ionotropic non-NMDA receptors, but do not affect on GMBF. However, L-glutamic acid showed no effect on acid secretion by itself.

並列關鍵字

L-glutamic acid ； histamine ； oxotremorine ； non-NMDA Receptor ； gastric acid secretion ； gastric mucosal blood flow