The Cooperative Phenomenon of Autonomic Nervous System in Urine Storage for Wistar Rats

Shyang Chang ； Meng-Ju Chiang ； Shiun-Jeng Li ； Shih-Jen Hu ； Hsiu-Yao Cheng ； Sheng-Hwu Hsieh ； Chen-Li Cheng

《The Chinese Journal of Physiology》 52卷2期 (2009/04) Pp. 14-22

https://doi.org/10.4077/CJP.2009.AMH015

並列摘要

The fractal dimension (FD) and spectral frequencies of physiological signals are two important indices in the study of physiological functions and dynamical diseases. The first index can be used to characterize the intensity and the second the rhythms of signals embedded in seemingly random data. Recent studies using both indices verified that synergic co-activations of bladder and external urethral sphincter (EUS) of Wistar rats were present during the voiding of urine. In this study, the primary aims were to (1) study if the involved muscles in the lower urinary tract would be under similar coactivations during the urine storage phase, and (2) characterize quantitatively the sympathetic and parasympathetic nerve activities simultaneously. Eighteen experiments were performed on six intact adult female Wistar rats and then the electromyogram of EUS and cystometrogram of bladder were analyzed. Results indicated that the EUS did not contain any significant spectral frequencies in the storage phase. Furthermore, its FDs (1.5918±0.0157) indicated that no appreciable amount of signal intensities was observed in the EUS. On the other hand, the bladder exhibited parasympathetic frequency of 8 Hz with signal-to-noise ratio (SNR)=19.9001 decibel (dB) for group mean, and sympathetic frequency of 19 Hz with SNR=22.8330 dB for group mean. In addition, its FDs (1.4796±0.0092) indicated relatively persistent intensities during storage as compared to that of EUS (1.5918±0.0157) with statistical significance (P＜0.01). We conclude that the EUS is not activated during the phase of storage. The bladder is under the cooperative, not antagonistic, sympathetic and parasympathetic nerve activities with discernible rhythmic frequencies and persistent intensities.

並列關鍵字

autonomic nervous systems ； dynamical disease ； fractional Brownian motion ； micturition ； reciprocal innervations ； synergic co-activation ； urine storage

參考文獻

Arneodo, A.,d''Aubenton-Carafa, Y.,Bacry, E.,Graves, P.V.,Muzy, J.F.,Thermes, C.(1996).Wavelet based fractal analysis of DNA sequences.Physica D.96,291-320.

Chancellor, M.B.,Yoshimura, N.,Walsh, P.C. (edited)(2002).Campbell's Urology.Philadelphia, PA:Saunders.

Chancellor, M.B.,Yoshimura, N.(2004).Neurophysiology of stress urinary incontinence.Rev. Urol..6(3),19-28.

Chang, S.,Hu, S.J.,Lin, W.C.(2004).Fractal dynamics and synchronization of rhythms in urodynamics of female Wistar rats.J. Neurosci. Meth..139,271-279.

Chang, S.,Li, S.J.,Chiang, M.J.,Hu, S.J.,Hsyu, M.C.(2007).Fractal dimension estimation via spectral distribution function and its application to physiological signals.IEEE Trans. Biomed. Eng..54,1895-1898.