Comparative Percutaneous Toxicity of Ten Industrial Solvents in the Guinea Pig

This report is part of a study on skin pathology, blood levels and percutaneous toxicity after the epicutaneous administration of solvents. The method used for the study of percutaneous toxicity differentiated between different types of solvents, and between different applied volumes of the same solvent. Five solvents caused some mortalities (in declining order: 2-chloroethanol, 1, 1, 2-trichloroethane, ethyleneglycolmonobutylether, carbontetrachloride, and dimethylformamide). Four solvents-benzene, toluene, 1, 1, I-trichloroethane, and trichloroethylene-did not cause mortality, but a statistically significant effect on weight gain was observed. For n-hexane the weight gain did not differ (P＞0.2) from that of the control animals exposed to distilled water. For comparison, the same amounts of the sol-vents were injected intraperitoneally. There was a fairly good agreement between intraperitoneal and percutaneous toxicity, but slight deviations were observed for carbontetrachloride and dimethylformamide.

並列關鍵字

Carbonatetrachloride ； dimethylformamide ； ethyleneglycolmonobutylether ； guinea pigs ； n-hexane ； intraperitoneal toxicity ； percutaneous toxicity ； 1, 1, 1-trichloroethane ； trichloroethylene

延伸閱讀

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Comparative Percutaneous Toxicity of Ten Industrial Solvents in the Guinea Pig

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