Biological Monitoring of Occupational Exposure to Tetrachloroethene

Aart Monster ； Wilma Regouin-Peeters ； Anneke van Schijndel ； Jan Van Der Tuin

《Scandinavian Journal of Work, Environment & Health》 9卷3期 (1983/05) Pp. 273-281

並列摘要

In the breathing zone of 32 workers concentrations of tetrachloroethene were measured during five consecutive workdays. The feasibility of biological monitoring was tested by the measurement of the concentrations of tetrachloroethene in blood and exhaled air and the urinary excretion of trichloroacetic acid and trichloroethanol. The best parameter to estimate the time-weighted average exposure to tetrachloroethene over the whole workweek appears to be the concentration of both tetrachloroethene and trichloroacetic acid in blood 15-30 min after the end of the workday at the end of the workweek. Among the noninvasive methods the best parameter is the tetrachloroethene concentration in exhaled air 15-30 min after work at the end of the workweek, followed by the measurement of trichloroacetic acid in urine at the end of the workweek. In exposure to 2,050 pmol of tetrachloroethene/m^3 (340 mg/m^3, 50 ppm) the estimated values for the biological parameters are 13.2μmol of tetrachloroethene/l of blood, 33 tun01 of trichloroacetic acid/l of blood, 920 μmol of tetrachloroethene/m^3 of exhaled air and 6.1μmol of trichloroacetic acid/mmol of creatinine in urine, respectively. With 95 % confidence it may be stated that an individual with a value for a biological parameter not exceeding 8.3μmol of tetrachloroethene/l of blood, 20μmol of trichloroacetic acid/l of blood, 515μmol of tetrachloroethene/m^3 of exhaled air and 3.0μmol of trichloroacetic acid/mmol of creatinine, respectively, had an exposure not exceeding 2,050μmol of tetrachloroethene/m^3. The measurement of trichloroethanol in urine may be used for the estimation of the time-weighted average exposure over the previous 2 d. The concentration of tetrachloroethene in exhaled air 15-30 min after exposure had little value for the estimation of the time-weighted average exposure over the last 4 h. On Monday morning the concentration of tetrachloroethene in exhaled air is still about 15% of the time-weighted average exposure concentration during the whole preceding workweek. The half-time of trichloroacetic acid in urine and blood during the weekend is about 65-90 h.

並列關鍵字

metabolism ； trichloroacetic acid ； trichloroethanol