Relative Risk of Mesothelioma Associated with Different Levels of Exposure to Asbestos

Timo Tuomi ； Matti S Huuskonen ； Matti Virtamo ； Antti Tossavainen ； Lauri Tammilehto ； Karin Mattson ； Aarne Lahdensuo ； Jorma Mattila ； Pekka Karhurien ； Kari Liippo ； Eero Tala

《Scandinavian Journal of Work, Environment & Health》 17卷6期 (1991/11) Pp. 404-408

並列摘要

The relative risk of mesothelioma associated with different levels of exposure to asbestos was evaluated. The exposure was assessed from work histories of 51 mesothelioma cases and 51 sarcoidosis referents. The lung fiber concentration of the mesothelioma patients was compared with that of two reference groups (13 random autopsy cases and 43 male lung cancer patients). When the categories definite and probable were used as an estimated probability of occupational exposure, an odds ratio of 17.7 [90 % confidence interval (90% CI) 3.4-253] and 3.0 (90% CI 0.9-10.6), respectively, was obtained. A lung fiber concentration of ＞ 1 million fibers/g of dry tissue as an indicator of accumulated exposure gave an odds ratio of 14.4(90% CI 2.5-178) for the men in comparison with the autopsy cases and 3.1 (90% CI, 1.3-7.5) in comparison with the lung cancer patients. Elevated risk of mesothelioma was shown to be associated with a lung fiber concentration of ＞1 million fibers/g of dry tissue.

並列關鍵字

electron microscopy ； mineral fibers ； work history