- 期刊
Experimental Study of Continuous Separation of Enantiomers by Simulated Moving Bed Chromatography
以模擬移動床層析法連續分離旋光性異構物的實驗研究
摘要
本研究是採實驗方法來探討以Pirkle D-Phenylgycine型的旋光性管柱所組成之模擬移動床(SMB)層析系統連續分離1-1’-Bi-2-naphthol混旋物的分離性能。SMB層析系統最適操作條件的選取係採用一種快速的方法，這個方法係基於三角理論，由理論中的完全分離區域來安排實驗操作點，然後透過一系列SMB層實驗來獲得系統之分離性能以及最適操作條件。這個方法也用來探討了各項操作參數(包括：進料流量、切換時間、注入濃度、管柱長度以及移動床配置等)對系統性能的影響。實驗結果顯示，採用管柱長度各為10cm的八床SMB層析系統可以得到很好的系統分離性能(各異構物的純度與回收率均可達98%以上)。
關鍵字
無資料並列摘要
The separation of 1,1’-bi-2-naphthol racemic mixtures using the simulated moving bed (SMB) method with chiral columns of Pirkle D-Phenylglycine was investigated experimentally in this study. A quick method was used to determine the optimal operating conditions for the SMB system. This was based on the “triangle theory,” and good separation conditions were found based on the experimental results of a series of SMB experiments conducted around the complete separation region of the “triangle theory.” This method was also used to study the effects of several operating parameters, including the feed flow rate, switch time, feed concentration, column length and bed configuration, on the SMB performance. Good separation (with purity and recovery of each isomer higher than 98%) was achieved for the model system in an eight-column SMB unit using a 10 cm column length.
延伸閱讀
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