Continuous Separation of Enantiomers by Simulated Moving Bed Chromatography: Effect of Operating Parameters on the System Performance

本研究探討Pirkle D-Phenylgycine型的旋光性管柱所組成之模擬移動床（SMB）層析系連續分離1-1'-bi-2-naphthol混旋物的分離性能。首先，建立一個考慮具有非線性平衡以及綜合質傳阻力與軸向擴散等效應之穩態真實移動床（TMB）模式，此TMB模式可以用來預測SMB系統的週期性穩態行為。利用「三角理論」來規劃選取SMB系統的操作參數，包括：各液相流量、切換時間、進料濃度、以及區長等。然後，透過此TMB模式的模擬分析，可以探討這些操作參數對SMB系統性能（包括：純度、回收率、溶劑耗量以及產率等）的影響，並進一步找出系統的較佳操作區域。這套分析工具可以用來選取SMB系統的最佳操作條件。

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並列摘要

The separation of 1,1’-bi-2-naphthol racemic mixtures by the simulated moving bed (SMB) method with chiral columns of Pirkle D-Phenylglycine was investigated in this study. First, a steady-state true moving bed (TMB) model, considering non-linear equilibrium, lumped kinetic and axial dispersion effects, was developed for predicting the cyclic steady-state behavior of the SMB system. The “triangle theory” was used to provide guidelines for the selection of feasible operating parameters of the SMB system, including liquid flow rates, switch time, feed concentration and zone length. Then, the effect of various operating parameters on the SMB performance, characterized by product purity, recovery, solvent consumption, and productivity, and the exact good separation region were studied through simulation of the TMB model. The package is an important tool to select the optimal operating conditions for the SMB operation.

並列關鍵字

Enantiomers ； Chiral columns ； Simulated moving bed ； System performance ； Optimal operation

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Continuous Separation of Enantiomers by Simulated Moving Bed Chromatography: Effect of Operating Parameters on the System Performance

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