The objective of this study was to investigate the effects of low doses of 3, 5, 3'-triiodo-L-thyronine (T3) in the growth parameters, liver DNA and soluble protein in hybride maletilapia (Oreochromis niloticus x O. aureus) by oral administration. Juvenile tilapia (n=135, mean body weight=1.08±0.04g) were divided into three groups and each fed for 8 weeks with formulated diet containing 0, 1 and 10 ppm of T3. Each group had 3 replicates and each replicate of fish was weighed biweekly. Body weight, gain, in weight, feed conversion efficiency, specific growth rate and feed consumption did not significantly differ among the control and T3-treated groups. Liver soluble protein content and protein/DNA ratio signifciantly increased in the 1 ppm T3 group as compared to those in the control group. No change of liver soluble protein and protein/DNA ratio was observed in the T3-treated tilapia fed at 10 ppm.