Diagnostic Value of Finger-guided Prostate Nodule Biopsy Combined with Systemic Random Biopsy

I-Ni Chiang ； Shang-Jen Chang ； Yeong-Shiau Pu ； Kuo-How Huang ； Hong-Jen Yu ； Chao-Yuan Huang

《Journal of the Formosan Medical Association》 108卷9期 (2009/09) Pp. 713-718

並列摘要

Background/Purpose: The purpose of this study was to compare prostate cancer detection rates and pathology results, using the Gleason grading system, of 12-core systemic random transrectal ultrasoundguided prostate biopsy (SB) and 3-core finger-guided prostate nodule biopsy (FGNB).
Methods: Between January 2002 and December 2006, 148 patients with digitally palpable prostate nodules received SB and additional FGNB. The prostate cancer detection rates and Gleason scores of positive cancer specimens were compared between SB and combination biopsy (SB + FGNB). The patients’ characteristics, including age, prostate specific antigen (PSA), percentage of free PSA and prostate volume were also recorded.
Results: With simple SB, FGNB, and combination biopsy, the prostate cancer detection rates were 39.9%, 37.9%, and 44.6%, respectively. Of the 66 patients with prostate cancer, the Gleason sum was underestimated in three patients with simple SB only and in one patient with FGNB only. The false-negative rates for SB and FGNB were 10.6% and 15.2%, respectively.
Conclusion: In patients with a palpable prostate nodule, combination biopsy with systemic and nodule biopsy could avoid some misdiagnoses of prostate cancer and provide more accurate information for pathology grading.

並列關鍵字

biopsy ； diagnostic techniques and procedures ； pathology ； prostate cancer