Effect of a Lactose-Free Milk Formula Supplemented with Bifidobacteria and Streptococci on the Recovery from Acute Diarrhoea

益生菌已被推薦用於嬰兒急性腹瀉的管理與預防上。在224位6－36個月大有嚴重急性腹瀉且沒有中度或嚴重營養不良的嬰兒上，進行一雙盲、隨機及安慰劑控制組的試驗。在由口或靜脈補充水分後，分為3組：無乳糖配方（控制組）；無乳糖配方公克奶粉加上10^8 CFU B. lactis Bb12和5x10^7 CFU St. thermophilus TH4；無乳糖配方分別加上10^8 CFU B. lactis Bb12與5x10^7 CFU St. thermophilus TH4。評估體位測量資料、腹瀉持續時間和輪狀病毒量。其中有87％的事件與輪狀病毒感染有關聯。腹瀉持續時間不受益生菌影響。然而，在餵食添加10^9 Bb12/g的配方奶的嬰兒上觀察到輪狀病毒量下降，使用這個物質可能具有流行病學的重要性。

關鍵字

嬰兒；急性腹瀉；輪狀病毒；益生菌；乳酸雙歧桿菌Bb12

並列摘要

Probiotics have been proposed for the management and prevention of acute diarrhoea in infants. A double-blind, randomised, placebo controlled study was carried out in 224 Chinese infants 6 to 36 months of age with severe acute diarrhoea and free from moderate or severe malnutrition. After oral or parenteral rehydration, they were allocated to one of three groups: a lactose-free formula (Control); the same formula but with viable 10^8 CFU B. lactis Bb12 and 5x10^7 CFU St. thermophilus TH4 per gram of powder and, the same formula with the same microorganisms, but with 10^9 CFU/g and 5x10^8 CFU, respectively. Anthropometric parameters, duration of the diarrhoea and rotavirus shedding were evaluated. Eighty seven percent of the episodes were associated with rotavirus infection. The duration of the diarrhoea was not influenced by the intake of probiotics. However, a decrease of rotavirus shedding was observed in infants fed the formula with 10^9 Bb12/g, a finding of probable epidemiological importance in the transmission of this agent.

並列關鍵字

infants ； acute diarrhoea ； rotavirus ； probiotics ； Bifidobacterium lactis Bb12

國際替代計量

Effect of a Lactose-Free Milk Formula Supplemented with Bifidobacteria and Streptococci on the Recovery from Acute Diarrhoea

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