- 期刊
Alcohol Consumption and Risk of Type 2 Diabetes Mellitus in Japanese: A Systematic Review
日本人酒精消耗量与2型糖尿病之风险关系：系统综述
摘要
目的：评价日本人群中酒精消耗量与2型糖尿病（DM）发病风险之间的关系。方法： 我们利用关键词'alcohol intake'（或者'alcohol consumption'） 和'Japanese'交叉结合'diabetes mellitus'（或者'impaired glucose tolerance'）在MEDLINE数据库中进行了检索。我们查询的文献限于前瞻性群组研究、随机对照试验、荟萃分析以及系统综述。计算机检索与手工检索在2007年6月实施。结果：采用了7项前瞻性群组研究的結果。我们以前的报告曾指出在体瘦的日本男性人群（身体质量指数（BMI）≤22.0 kg/m^2）中，中度至重度酒精摄入是糖尿病的一项危险因素。有一项研究发现在低BMI男性中，重度酒精摄入增加了糖尿病风险；而在高BMI男性中，中度酒精摄入却减少了糖尿病风险。另一篇报告提示日常的酒精消费量对于低BMI者是一项危险因素，但是对于中等BMI者却有保护作用。然而，另一个研究顯示在日本男性中，酒精消费量与糖尿病风险呈U-型关系。在另外3项未按照BMI值区分试验对象的研究中，都指出酒精摄取会增高糖尿病的发病风险，其中两项研究的对象为男性，另一项研究針对女性。结论：对于BMI较低的多数日本男性而言，酒精摄入是糖尿病的一项已確認的危险因子。
並列摘要
Objective: To evaluate the association between alcohol consumption and the risk for type 2 diabetes (DM) in Japanese. Methods: We searched the MEDLINE data base with the key words 'alcohol intake' (or 'alcohol consumption') and 'Japanese' cross-linked with 'diabetes mellitus' (or 'impaired glucose tolerance'). The reports we sought were restricted to prospective cohort studies, randomized controlled trials, meta-analyses and systematic reviews. Computerized and hand searches were conducted in June 2007. Results: Seven prospective cohort studies were adopted. We previously reported that in lean Japanese men (BMI ≤22.0 kg/m^2), moderate to heavy alcohol intake is a risk factor for diabetes. One study found heavy alcohol intake to be associated with an increased risk in low-BMI men while moderate alcohol intake was associated with a reduced risk in higher-BMI men. Another study suggested daily alcohol consumption to be a risk factor in low-BMI participants, while being protective in middle-BMI participants. Yet another study demonstrated a U-shaped association between alcohol consumption and the risk of diabetes in men. Three other studies, which did not divide the subjects in terms of BMI values, indicated alcohol intake to be an increased risk for diabetes, two being in men and one being in women, respectively. Conclusion: For a large number of Japanese men who have relatively low BMI, alcohol intake is an established risk factor for diabetes.
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延伸閱讀
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