Relationship between Dietary Fat and Fish Intake and the Prevalence of Atopic Eczema in Pregnant Japanese Females: Baseline Data from the Osaka Maternal and Child Health Study

日本孕婦在飲食脂肪和魚的攝取與遺傳過敏性溼疹之盛行率之相關性：大阪母親與孩童健康研究之基綜資料

Yoshihiro Miyake ； Satoshi Sasaki ； Keiko Tanaka ； Yukihiro Ohya ； Ichiro Matsunaga ； Toshiaki Yoshida ； Yoshio Hirota ； Hajime Oda

《Asia Pacific Journal of Clinical Nutrition》 17卷4期 (2008/12) Pp. 612-619

https://doi.org/10.6133/apjcn.2008.17.4.12

摘要

在遺傳過敏性溼疹發展過程中，飲食因子可能是重要的。不論是攝取n-3多元不飽和脂肪酸可防止過敏的論點，或攝取n-6多元不飽和脂酸會增加過敏性的風險都仍然是有爭議的。本篇橫斷性研究就是在檢測脂肪酸和高脂肪食物攝取與遺傳過敏性溼疹之盛行率的相關性。研究對象是1002位日本孕婦。目前的遺傳過敏性溼疹和18歲之後的遺傳過敏性溼疹，被定義為當受試者分別在12個月前和滿18歲後已經接受藥物治療，那就是有遺傳過敏性溼疹。飲食因子資訊，是使用一個有效的自我填答飲食史問卷收集得來的。DHA攝取顯著性地與18歲之後和目前的遺傳過敏性溼疹盛行率的降低有相關。不論n-3多元不飽和脂肪酸、EPA、魚和n-3/ n-6多元不飽和脂肪酸比值對遺傳過敏性溼疹並沒有負的劑量效應，但這些飲食變項的第二個參等分與18歲之後的遺傳過敏性溼疹呈顯著地負相關。總脂肪、飽和脂肪酸、單元不飽和脂肪酸、n-6多元不飽和脂肪酸、膽固醇、肉、蛋或是乳製品攝取與任一項遺傳過敏性溼疹都沒有相關。在日本孕婦中，DHA 攝取可能與遺傳過敏性溼疹盛行率的減少有相關性存在。

關鍵字

遺傳過敏性溼疹 ； 飲食 ； 脂肪酸 ； 魚類 ； 日本

並列摘要

Dietary factors may be important in the development of atopic eczema. It remains controversial whether n-3 polyunsaturated fatty acid intake is preventive against allergic disorders and whether n-6 polyunsaturated fatty acid intake increases the risk of allergic disorders. The current cross-sectional study examined the association between intake of fatty acids and foods high in fatty acids and the prevalence of atopic eczema. Study subjects were 1002 pregnant Japanese females. Current atopic eczema and atopic eczema after age 18 were defined as present if subjects had been treated with medications at some time in the previous 12 months and after reaching the age of 18, respectively. Information on dietary factors was collected using a validated self-administered diet history questionnaire. Docosahexaenoic acid intake was statistically significantly related to a decreased prevalence of atopic eczema after age 18 and current atopic eczema. Inverse dose-response relationships with regard to consumption of n-3 polyunsaturated fatty acids, eicosapentaenoic acid, and fish and the ratio of n-3 to n-6 polyunsaturated fatty acids with atopic eczema were not observed although these dietary variables in the second tertile were inversely significantly associated with atopic eczema after age 18. Intake of total fat, saturated fatty acids, monounsaturated fatty acids, n-6 polyunsaturated fatty acids, cholesterol, meat, eggs, or dairy products was not related to either of the outcomes for atopic eczema. Docosahexaenoic acid intake may be associated with a reduced prevalence of atopic eczema in pregnant Japanese females.

並列關鍵字

Atopic eczema ； eating ； fatty acids ； fishes ； Japan