Relationship between Changes of Bone Mineral Density over Seven Years and A1330V Polymorphism of the Low-density Lipoprotein Receptor-related Protein 5 Gene or Lifestyle Factors in Japanese Female Workers

日本女性僱員的骨密度改變與低密度脂蛋白受體相關蛋白5的基因型或生活型態有相關

Yayoi Funakoshi ； Hisamitsu Omori ； Hironori Yada ； Takahiko Katoh

《Asia Pacific Journal of Clinical Nutrition》 19卷4期 (2010/12) Pp. 534-539

https://doi.org/10.6133/apjcn.2010.19.4.12

摘要

以一個縱貫性研究來探討七年間骨密度（BMD）的改變與低密度脂蛋白受體相關蛋白5（LRP5）基因A1330V多型性或生活型態因子間的關係。受試者為日本一個大型綜合製造廠的僱員，共包含113位停經前婦女，納入研究時平均年齡為25.6±4.2歲。以雙能X光骨密度儀（DXA）測量橈骨決定骨密度。生活型態方面資訊則以問卷取得。LRP5基因的不同型頻率分別為52%（AA）、39%（AV）及9%（VV）。七年後，只有在基因型為AV與VV的受試者，其骨密度有顯著的減少（0.463 ± 0.045至0.456 ± 0.046g/m2）。在校正年齡與身體質量指數後，發現有飲酒的受試者，當其有AV與VV的基因型，比起基因型為AA的人，骨密度變化更大（F=4.547, p=0.036）。調查LRP5基因A1330V多型性可能有助於辨識個體是否易患骨質疏鬆症，以提供早期的預防方法。

關鍵字

骨質密度 ； 基因多型性 ； 日本 ； 生活型態 ； 低密度脂蛋白受體相關蛋白5基因

並列摘要

A longitudinal study was conducted to investigate the relation between the changes of bone mineral density (BMD) over a seven-year period and A1330V polymorphism of the low-density lipoprotein receptor-related protein 5 (LRP5) gene or lifestyle factors. The subjects were 113 premenopausal female employees from a large-scale integrated manufacturing facility in Japan aged 25.6±4.2 years (mean ± standard deviation) at baseline. BMD was measured at the radius by dual energy X-ray absorptiometry. Lifestyle information was obtained by a questionnaire. The genotype frequencies of LRP5 gene polymorphism were 52%, 39%, and 9% for AA, AV, and VV, respectively. After seven years, BMD showed a significant decrease (from 0.463 ±0.045 to 0.456 ± 0.046 g/m^2) in subjects with the AV or VV genotypes, but not in subjects with the AA genotype. Analysis of covariance with adjustment for age and body mass index showed that subjects who drank alcohol displayed a significantly greater change of BMD if they had the AV or VV genotype than if they had the AA genotype (F=4.547, p=0.036). Investigation of LRP5 A1330V polymorphism may be useful for identifying individuals who are susceptible to osteoporosis, allowing early preventive measures to be provided.

並列關鍵字

bone mineral density ； genetic polymorphism ； Japan ； lifestyle ； low-density lipoprotein receptor-related protein 5 gene